Vaccine and Infectious Disease Organization -
International Vaccine Centre

Chlamydia trachomatis and Neisseria gonorrhoeae - animal model and vaccine development

Project Team: Jo-Anne Dillon, Volker Gerdts, Heather L. Wilson, S. Dev

Chlamydia trachomatis and Neisseria gonorrhoeae are two of the most common sexually transmitted bacterial pathogens. These bacteria cause urogenital mucosal infections and left untreated may lead to severe complications including pelvic inflammatory disease, infertility and ectopic pregnancies in women, and prostatitis, epididymitis and involuntary infertility in men.

We developed a porcine model for chlamydia infections to characterize the host response to infection and to evaluate novel vaccine candidates. Research indicates this model can be used to study pathology, pathogenesis and immune responses to infections with Chlamydia. Steps are underway to establish a porcine model for gonorrhea infections. These models will allow us to evaluate novel experimental vaccine candidates in a more relevant environment.