VIDO-InterVac

Vaccine and Infectious Disease Organization -
International Vaccine Centre

Vaccine development for Porcine Epidemic Diarrhea

Project Leaders: Volker Gerdts, Yan Zhou, Brenda Allan, Alexander Zakhartchouk, Heather L. Wilson

Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus of pigs first isolated in the United Kingdom in the 1970s. Since then the disease spread to many parts of Europe and Asia and recently emerged in North America, where it has killed more than 7 million pigs since then. The virus is highly infectious and survives well in the environment making it difficult to control though biosecurity and management practices. PEDV represents an enormous threat to the Canadian swine industry, and as such, resources have been invested into disease control including early and rapid detection, disease surveillance and enhanced biosecurity.

Prior to the first identified case in Canada, VIDO-InterVac initiated the development of an experimental inactivated of vaccine. This vaccine has been successful in preclinical trials, and further safety and efficacy testing under commercial conditions is ongoing.Our research is also targeted at development of a next generation vaccine for PEDV.

Objectives:

  • Develop a safe and effective PEDV vaccine for Canadian swine producers